Frequency of Vitamin D Deficiency in PCOS Patients Presenting at A Tertiary Care Hospital

Abstract

Objective: To document the incidence of vitamin D deficiency among patients presenting with Polycystic ovarian Syndrome (PCOS) in a large tertiary care centre in Karachi.

Methodology: This descriptive cross-sectional study was conducted in the Department of Obstetrics & Gynecology, Jinnah Postgraduate Medical Centre, Karachi from 30^th October 2018 to 29^th April 2019. A total of 95 patients with polycystic ovarian syndrome, 18 to 45 years of age were included. Patients with hyperthyroidism, vitamin D therapy for > 3 months, heart failure, long term steroid treatment and acid peptic disease were excluded. Blood Samples were drawn and sent to the chemistry lab on the same day for determining Vitamin D levels.

Results: Mean age of our study participants was 32.60 ± 4.77 years (18 to 45 years). Majority of the patients i.e. 66 (69.47%) were between 31 to 45 years of age. Mean duration of symptoms was 6.34 ± 2.46 months (3 to 9 months). Mean BMI was 29.45 ± 3.13 kg/m² (26 to 32 kg/m²⁾ (Table 1).Vitamin D deficiency was seen among 41 (43.16%) patients with a mean level of 16.67ng/ml ±3.12ng/ml (13.9ng/ml-18.5ng/ml). The lowest levels of serum vitamin D were found in women with a BMI of >30 kg/m². There were 26 unmarried participants and 69 married ones with vitamin D deficiency seen in 46.15% and 42%, respectively.

Conclusion: This study concluded that frequency of vitamin D deficiency in PCOS patients is quite high, especially among women with a BMI>30 kg/m²