Shaheen Basheer, Zaiba Sher, Mussarat Ashraf
|Address of Correspondence
Dr. Mussarat Ashraf, Assistant Professor,
Department of Obstetrics and Gynaecology, PAEC General Hospital,
Objective: in this study we compared the efficacy of
conventional dinoprostone alone and concurrent oxytocin with dinoprostone
in reducing induction delivery interval in primigravida at term.
Minimizing induction delivery interval will result in improved
maternal satisfaction with birth process and less hospital cost
by reducing hospital stay.
It was hypothesized that the concurrent method of labour induction
would lead to shorter induction to delivery time without any adverse
foetal or maternal effects.
Study Design: a randomized controlled trial.
Place & duration of study: department of Obstetrics and Gynaecology,
PAEC General Hospital, Islamabad from August 1st, 2009 to January
Methodology: eighty pregnant women at term were
randomly assigned to either dinoprostone and concurrent oxytocin
group (Group A, n=40) or dinoprostone alone with placebo group
(Group B, n=40). Induction delivery interval, mode of delivery,
maternal complications (e.g. hyperstimulation) and foetal complications
(e.g. NICU admission and APGAR score after birth of neonate) were
Results: It was found that induction to delivery
interval in concurrent oxytocin group (Group A) was significantly
reduced as compared to dinoprostone alone group (Group B). In
group ‘A’ 22.5% patients delivered in 3-5hrs while
in only 7.5% patients induction delivery interval was 10-16hrs
as compared to group ‘B’ where 25% patients delivered
in 10-16hrs (p value 0.026). The operative delivery i.e. lower
segment caesarean section (LSCS) was performed in 27.5% and 32.5%
patients in group ‘A’ and group ‘B’ respectively.
Hyperstimulation rate in group ‘A’ was slightly higher
(5% patients) than group ‘B’( 2.5% patient). There
was no statistically significant difference in APGAR score and
Neonatal Intensive Care Unit (NICU) admissions in babies born
in both groups.
Conclusion: induction delivery interval in concurrent
method of induction was significantly less as compared to dinoprostone
alone group without increasing foetomaternal risks.
Keywords: term, Primigravida, Dinoprostone, Induction
of labour, Induction delivery interval, Concurrent oxytocin
[Download Complete Original
Format File Size: 391 KB(PDF)
Format File Size: 1.76 MB(PDF)