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Association of Serum Folate Levels with Neural Tube Defects Original Article
Author(s) Name:
Shah Muhammad Khan Jadoon, Samina Jadoon
Address of Correspondence
Dr Samina Jadoon, Assistant Professor Department of Obs & Gynae , Mardan Medical Complex Teaching Hospital Mardan

Objective: The aim of this study was to assess the association of serum folate levels with the neural tube defects.
Study Design:  Descriptive cross-sectional study.
Place and duration of study: Department of OBGYN-Unit B, Mardan Medical Complex Teaching Hospital Bacha Khan Medical College, From 1st January, 2015 to 31st December 2015.
Methodology: This study was conducted at the OBGYN-Unit B, Mardan Medical Complex Teaching Hospital, from 1st January, 2015 to 31th December 2015. All pregnant women who were diagnosed on ultrasound having fetuses with neural tube defects were included while patients with neural tube defects and other congenital anomalies, diabetes and taking anti seizure drugs were excluded. The data was collected on the prescribed proforma. SPSS version 19 was used for statistical analysis.
Results: Total numbers of obstetrical admissions during the study period were 4230. Fifty patients (1.18%) with neural tube defects were selected. Sixteen women (32%) were between 17-25 years of age,31 (62%) were between 26-35 years of age and 3(6%) were between 36-45 years of age. The primigravida were 21(42%) and multigravida were 29 (58%). All were unbooked and no one had taken folic acid during first trimester. All delivered fetuses were examined for gender and it showed that 30 fetuses were females (60%) and 20 were males (40%). Majority of patients, 43 out of 50(86%), had serum folate levels below 3.1ngm/ml and only 7 patients (14%) were within normal range.
Conclusion:  Low serum folate levels are strongly associated with neural tube defects. This finding shows that food fortification with folic acid can reduce the prevalence of NTDs.
Key words: Anencephaly, Folic acid, Neural tube defects (NTDs),  Spina bifida.

Cite this article: Jadoon Shah MK, Jadoon. S Association of Serum Folate Levels with Neural Tube Defects. J. Soc. Obstet. Gynaecol. Pak. 2016; Vol 6(1):26-28.

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