Correlation of Anti-Müllerian Hormone (AMH) with Antral Follicular Count

Abstract

Objective: To determine the correlation between serum Anti-Müllerian Hormone levels and antral follicular count in infertile women.

Methodology: The study was a cross-sectional analytical research done in the Department of Gynaecology and obstetrics, PAEC general hospital, Islamabad between June and August 2020. Non-probability consecutive sampling was used to sample 103 infertile women aged 20-40 years. The level of serum AMH, FSH, LH, and estradiol was measured in the early follicular phase (Day 23). To evaluate bilateral AFC and ovarian volume, transvaginal ultrasound was done. The SPSS version 26 was used when analysing data. The KolmogorovSmirnov test was used to test whether there is normalcy and Pearson correlation coefficient. The p-value of 0.05 was taken as significant.

Results: The mean serum AMH level was 4.04 ± 1.95 ng/mL, and the mean total AFC was 19.69 ± 6.68. No statistically significant correlation was observed between serum AMH and total AFC (r = 0.044, p = 0.658). Serum AMH also showed no significant association with ovarian volume or age.

Conclusion: Serum AMH did not show a significant correlation with antral follicular count in this cohort. Assessment of ovarian reserve should therefore incorporate both hormonal and ultrasonographic parameters.