Association of Vitamin D with Uterine Fibroid in Women of Reproductive Age

Shamila Ijaz; Sajida Razzaq; Aleena Sarwar; Ayesha Sial; Qurat ul Ain

doi:10.71104/jsogp.v16i2.954

Shamila Ijaz Professor of Obs &Gynae,Fatima Jinnah Medical University,Lahore
Sajida Razzaq Medical Officer, Sir Ganga Ram Hospital, Fatima Jinnah Medical University, Lahore
Aleena Sarwar Assistant Professor, Obs & Gynae, Fatima Jinnah Medical University, Lahore
Ayesha Sial Medical Officer, Sir Ganga Ram Hospital, Fatima Jinnah Medical University, Lahore
Qurat ul Ain Urogynae Postgraduate Trainee, Fatima Jinnah Medical University, Lahore

DOI: https://doi.org/10.71104/jsogp.v16i2.954

Keywords: Uterine fibroid, vitamin D deficiency, vitamin D Supplementation.

Abstract

Objectives: To determine the mean change in fibroid size after vitamin D supplementation in Vitamin D deficient women visiting a tertiary care hospital of Lahore.

Methodology: This quasi-experimental trial study was conducted in department of Obstetrics and Gynecology, Sir Ganga Ram hospital, Lahore. from July 2022 to June 2023. A total of 115 premenopausal women between 40 and 45 years of age having fibroids of less than 5 cm by ultrasound were checked for vitamin D levels. The women having vitamin D levels less than 20ng/ml were included. Vitamin D 200,000IU oral supplementation, once weekly was given till the vitamin D level reached 50ng/ml or above or for 12 weeks’ duration whichever was earlier. After 12 and 24 weeks all women had an ultrasound and a difference in size and volume of the uterine fibroid was noted. Mean and standard deviation were calculated for numerical variables like Age, duration of symptoms, BMI and size of fibroid (pre, post and change). Post-stratifications, independent ‘t’ test was applied taking p ≤ 0.05 as statistically significant.

Results: The mean fibroid size at baseline and post-treatment was 34.23 ± 9.66 mm and 27.18 ± 9.39 mm respectively (p-value <0.0001). Mean change in fibroid size after vitamin D Supplementation in Vitamin D deficient women was 6.79 ± 1.98 mm.

Conclusion: This study concluded that Serum Vitamin D level inversely correlated with size of uterine fibroid and possibly supplementation of vitamin D reduces size of fibroid in vitamin deficient women.