Dr. Aalia Jadaan, Department of Obstetrics & Gynaecology, Aziz FatimahTrust Hospital and Medical and Dental College, Faisalabad

ABSTRACT
Objective: to investigate cause of primary amenorrhoea among patients presenting at Aziz Fatimah Hospital, Faisalabad.
Study Design: descriptive cross sectional study.
Duration of Study: the study was conducted in Department of Obstetrics & Gynecology, Aziz Fatimah Trust Hospital and Medical and Dental College Faisalabad, for a duration of 1 year from May, 2014 to April 2015.
Methodology: fifty six patients presenting with primary amenorrhoea were enrolled for the study after history, examination and necessary investigations. The patients of age 16 to 40 years who never had menstruation in life were included in this study. Patients with surgical causes of amenorrhoea and secondary amenorrhoea were excluded from the study. All the required information was recorded on a predesigned Performa.
Results: the mean age of group was 19.46 ± 3.54 years. Majority of the patients 37(66.07%) had height in the range of 126-150cm and 6 (10.71%) patients had height less than 100cm. Weight of main bulk (35.71%) of patients was 46-50 kg.
In this sample 21 (37.50%) patients had infantile breast development, the pubic hair was infantile in 20 (35.71%) patients and axilliary hair was infantile in 17 (30.36%) patients. It was found that main causes of the amenorrhoea in these patients were related to anatomical defects in 25 (44%) patients. Followed by chromosomal defects which were found in 17 (31%) patients and Hypothalamic-pituitary-ovarian (HPO) axis defects were recorded in 10(18%) patients. In 4 (7%) patients some other defects (like TB endometritis) were noted.
Conclusions: Though different treatment modalities are available but outcome regarding regular menses and fertility potential is not so satisfactory. With continuing advancement of technologies of artificial reproduction there is still hope for some patients with primary amenorrhoea to have their genetic offspring.
Key words: primary amenorrhoea, anatomical defects, chromosomal defects, kuster-hauser syndrome.

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