The Overexpression of P53 Frequency in Epithelial Ovarian Cancer

Abstract

Objective: To determine the frequency of P53 overexpression in epithelial ovarian cancer.

Methodology: The cross-sectional study was conducted at the Department of Pathology, KRL Hospital Islamabad, from April 2018 to October 2019. Ninty four biopsy specimens using Non-probability consecutive sampling technique from the gynaecology department patients aged between 25-65 years, Biopsies and resected specimens of all adult females diagnosed by histopathologist as epithelial ovarian cancer was chosen. Immunohistochemical processing was performed using a Dako M7007 Kits were used applying FISH method. Results were interpreted by the consultant pathologist for overexpression (positive/negative) of p53. All this data was recorded on a predesigned proforma.

Results: An average of 47.00 years and a standard deviation of 10.80 years were found among the participants in this study. On average, the illness persisted for 5.79 2.00 months, with a mean. age of 46. Ovarian cancer was found in 12.77% of the patients (n = 12). In 34 (36.17%) of the cases of epithelial ovarian cancer, p53 overexpression was found.

Conclusion: Epithelial ovarian cancer has had a high prevalence of P53 overexpression. Immunostaining of p53 in epithelial ovarian cancer may improve overall health and reduce mortality and morbidity for the general population.